Dr.Althea · PDRN Reju 5000 Cream · 20 g · US Formula
Looks like an ointment. Melts like an ampoule.The PDRN cream for skin that feels tight, dull and over it by 4 p.m.
Dr.Althea PDRN Reju 5000 Cream pairs 5,000ppm PDRN (listed as sodium DNA) with 5% panthenol, 5% centella leaf water and three forms of hyaluronic acid in a featherlight cream that leaves skin bouncier-looking, smoother-looking and comfortably hydrated. It's from the Korean brand behind the 345 Relief Cream, sits on the Dr.Althea shelf at Ulta and Olive Young US, and is 100% authentic at MIMOMART.
Bouncy-lookingDeep comfortNo greasy filmLayer where you need it
PDRN without the heavy texture. A trending K-beauty ingredient at a stated 5,000ppm, in a cream that glides on like a hydrating ampoule and disappears without a slick finish.
Comfort first. Panthenol and centella leaf water sit near the top of the US ingredient list, so skin that feels tight or stressed gets cushioning moisture, not just shine.
One tube, two jobs. A thin layer as your daily moisturizer, a thicker layer on dry patches or as an overnight mask.
The Receipts
Dr.Althea PDRN Reju 5000 Cream by the numbers: what's actually in the tube
5,000ppm PDRN (sodium DNA), the "5000" in the name
5%panthenol, listed fourth on the US label
3forms of hyaluronic acid for layered hydration
+16.75%skin-texture score after 2 weeks, brand-reported trial
Concentrations as stated by Dr.Althea on US retail listings, checked October 2026. Trial figure as reported by Dr.Althea: Korea Institute of Dermatological Sciences study, September–October 2025, measured after 2 weeks. Individual results vary.
Why It Went Viral
How Dr.Althea went from a Korean derma brand to the US beauty aisle
Dr.Althea's name traveled on the back of one cream. The 345 Relief Cream blew up on TikTok, beauty editors in the UK started calling Dr.Althea the K-brand they actually use, and US shoppers followed. The brand says it has sold more than 26 million units of 345 worldwide. Then Ulta and Olive Young US put the line on American shelves.
PDRN Reju 5000 Cream is the brand's answer to the PDRN craze. PDRN used to belong to in-clinic Korean skin treatments, and it is now the hottest word in topical skincare. Dr.Althea skipped the heavy salve and made a light, everyday cream. Stylist's beauty team called it a new favorite, and BuzzFeed put it at #1 in an October 2026 roundup for its "lightweight texture reviewers love."
2014 · Korea
Dr.Althea launches as a Korean derma skincare brand built around formulas for sensitive skin.
2023 · North America
The brand enters North America. It later reports 1,415% North American sales growth in its first two years.
Sept–Oct 2025 · Ulta Beauty
Dr.Althea debuts on Ulta.com in September, then in 109 Ulta stores on October 26, with a rollout planned to 1,350 locations.
March 2026 · Global
Jang Wonyoung of IVE is named Dr.Althea's global brand ambassador.
May 2026 · Los Angeles
Dr.Althea lands in Olive Young US stores starting in Pasadena, and PDRN Reju 5000 Cream is the only PDRN product in the launch lineup.
One Tube, Two Modes
Dr.Althea PDRN Reju 5000 Cream as a daily moisturizer or an overnight cushion
Mode 1 · Daily layer
Thin veil + sunscreen
Warm a pea-sized amount between your fingertips and press it over your face as the last step before SPF. It sinks in fast and sits flat, so makeup goes on smoothly over it. Skin looks fresh, not shiny.
AM & PM · every day
Mode 2 · Spot & sleep
Thick layer + lights out
Leave a generous layer over the whole face as a leave-on night mask, or dot extra on the spots that always feel tight: cheeks, around the nose, the jawline. You wake up to soft, plump-looking skin.
PM · dry nights, retinoid nights, flights
The Formula Philosophy
Why a light PDRN cream beats a heavy "recovery" balm for everyday use
Water-based comfort. Centella leaf water and panthenol do the cushioning, so the cream can feel generous without a thick oil layer on top.
Three sizes of hyaluronic acid. Sodium hyaluronate, hyaluronic acid and hydrolyzed hyaluronic acid bind water at different levels of the skin's surface for a plumper, dewy look.
Slip from lightweight silicones. Vinyl dimethicone, caprylyl methicone and dimethiconol give the silky, ampoule-like glide and a smooth-looking finish under makeup.
PDRN as the headline. Sodium DNA conditions the skin and leaves it feeling soft. Its job here is to make skin look bouncier and smoother, not to replace an in-office treatment.
Polydeoxyribonucleotide is a mix of DNA fragments, and it has become K-beauty's ingredient of the moment. Dr.Althea lists it at 5,000ppm, which is 0.5%. In a cream, think of it as a conditioning ingredient that leaves skin feeling soft and looking smoother and bouncier.
Panthenol (pro-vitamin B5)Panthenol
Comfort · Humectant
Dr.Althea states 5%. Panthenol draws in water and leaves skin feeling calm and soft, which is why it shows up in so many post-sun and "sensitive skin" formulas.
Centella leaf waterCentella Asiatica Leaf Water
Soothing feel
Also stated at 5% and listed third, right after water and glycerin. Centella is Korea's classic choice for skin that looks red or feels stressed. Here it is part of the water phase, not a trace extract.
These are the workhorse humectants, and glycerin is the second ingredient on the US label. They're a big reason the cream feels so hydrating for its weight. We list them because they matter, even if they aren't the stars.
A lab-made peptide, the antioxidant vitamin E and a plant sterol round out the formula. They come near the end of the list, so they're supporting players, not headliners.
These give the cream its silky slip and a smooth-looking finish without a greasy feel. If you avoid silicones, note that some ingredient databases wrongly tag this cream as silicone-free.
Editor's note on "5000" and where the PDRN comes from: "5000" is the PDRN concentration (5,000 parts per million = 0.5%), not an ingredient count or a percentage. On the US label PDRN appears as "Sodium DNA," in 14th place, after the panthenol and centella. That is normal for a potent ingredient at 0.5%. Retailers don't agree on where the PDRN comes from. Dr.Althea calls it "Biome PDRN," several shops describe it as probiotic-derived, and at least one retailer says salmon-derived. The INCI name sodium DNA doesn't say which. Ulta lists the cream as vegan. If the PDRN source matters to you, the brand's own packaging is the final word.
How It Compares
Dr.Althea PDRN Reju 5000 Cream vs. 345 Relief Cream vs. a basic gel moisturizer
Which Dr.Althea cream should you pick? If your skin is oily or combination, shows redness-looking areas, and you want a niacinamide-based all-rounder, choose the Dr.Althea 345 Relief Cream. If your skin feels tight, looks dull or loses its bounce, especially in winter or on retinoid nights, choose PDRN Reju 5000 Cream. Plenty of people own both: 345 in the morning, Reju 5000 as the cushioning night layer.
PDRN Reju 5000 Cream
Dr.Althea 345 Relief Cream
Basic gel moisturizer
Built for
Dry, tight, dull-looking skin that wants bounce and comfort
Oily or combination skin with redness-looking areas
Quick, light hydration
Headline ingredients
5,000ppm PDRN, 5% panthenol, 5% centella leaf water, triple HA
Niacinamide, resveratrol, centella and a soothing botanical blend
Usually glycerin + hyaluronic acid
PDRN
Yes, the headline, at a stated 5,000ppm
Plant-derived PDRN in the newer formula; amount not stated
Usually none
Texture
Ampoule-light cream from an ointment-style tube
Light cream
Watery gel
Night-mask use
Yes, the brand suggests a thick overnight layer
Works as a light night cream
Often too light alone
Size
20 g tube
50 ml
Varies
Comparison based on publicly listed ingredients and product descriptions. 345 Relief Cream details from public ingredient listings and editorial coverage, checked October 2026. Formulas can change, so check the label.
Who It's For
Who Dr.Althea PDRN Reju 5000 Cream is for: made for you if your skin is…
Dry or dehydrated and tight after cleansing
Dull-looking and short on bounce
Sensitive and happiest with fragrance-free formulas
Normal to combination and wants a light moisturizer
Using retinoids or acids and wants a comforting layer
Curious about PDRN without a heavy salve
Mature and after a smoother, plumper look
Flaky in patches but fine everywhere else
Patch test first if: you react to centella, panthenol, olive-derived emulsifiers (cetearyl olivate, sorbitan olivate) or fermented ingredients (Aureobasidium pullulans ferment), or you know you're sensitive to silicones. Try it on your jaw or inner arm for a few days first. Don't apply it to broken skin or open wounds. If you've just had an in-office procedure, ask your provider when to start your skincare again.
Dr.Althea suggests a thick layer as a night mask. Skip rinsing. You wake up to skin that looks rested and feels soft.
02
The retinoid-night buffer
Beauty bloggers report using it on retinol nights to keep that tight, dry feeling away. Put it on after your retinoid, or sandwich the retinoid between two thin layers.
03
Zone layering
One thin layer all over, then a second pass on dry cheeks or around the nose. The brand calls this spot care, and it means one cream works for combination skin.
04
Carry-on comfort
The 20 g tube fits in a pouch for flights and dry offices. Press a little over makeup-free areas or onto dry knuckles when skin feels tight.
What Reviewers Keep Saying
Dr.Althea PDRN Reju 5000 Cream reviews: the pulse
Top praise
Lighter than the tube suggests
Reviewers and editors expect a thick balm and get a cream that melts in fast with no greasy residue.
Surprise favorite
Soft, smooth skin by morning
The most common note is skin that feels softer and looks smoother, and some users rely on it after retinol.
Honest critique
A small tube for the money
The 20 g tube is small, and some reviewers tag it "expensive." Fix: use a pea-sized amount for daily wear and save thick layers for dry nights.
Themes summarized from Skinsort review tags, Lola's Secret Beauty Blog, Stylist and BuzzFeed, October 2026. Headlines summarize common themes; they are not quotes from individual customers.
How to Use
How to use Dr.Althea PDRN Reju 5000 Cream for the bounciest-looking finish
1
Cleanse gentlyUse a mild cleanser suited to your skin type and pat dry, leaving skin slightly damp.
2
Toner and serum firstApply your toner, then your serums. This cream goes on last or second to last.
3
Press, don't rubSpread a pea-sized amount evenly over your face and pat gently until it sinks in. Use it morning and night.
4
Finish with SPF in the morningPut sunscreen on top for daytime. The cream sits flat, so it doesn't pill under SPF or makeup.
+
Spot care or night maskAdd a thicker layer on dry areas, or leave a generous coat on all night.
Pro tips from people who use it daily
Less is more by day. One pea-sized amount covers the whole face, and a thin layer looks fresher under makeup.
Lock in damp skin. Apply within a minute of your last water-based step so the hyaluronic acid has water to hold.
Pair it with 345. Use the 345 Relief Cream on oily zones and Reju 5000 on dry ones if your skin type changes across your face.
Know Before You Buy
Honest notes from the MIMOMART team
It's 20 g. That's a small tube, made for daily thin layers and spot care. If you plan nightly thick masks, buy two.
It isn't an in-office treatment. PDRN in a cream is cosmetic. Expect softer, bouncier-looking, smoother-looking skin, not clinic results.
It contains silicones. They give the silky slip. If you avoid silicones, this isn't your cream.
The PDRN source isn't printed on the US ingredient list. See the editor's note above.
It's fragrance-free, so there's no added scent.
FAQ
Dr.Althea PDRN Reju 5000 Cream: your questions, answered
What does PDRN Reju 5000 Cream by Dr.Althea do?
It's a lightweight moisturizer that hydrates and comforts skin. It leaves skin feeling soft and looking bouncier and smoother. The formula pairs PDRN (sodium DNA) at a stated 5,000ppm with 5% panthenol, 5% centella leaf water and three forms of hyaluronic acid.
Dr.Althea PDRN Reju 5000 Cream vs. 345 Relief Cream: which should I buy?
Choose the 345 Relief Cream if your skin is oily or combination and you want niacinamide and resveratrol in a light all-rounder. Choose PDRN Reju 5000 Cream if your skin feels dry or tight, looks dull, or needs a cushioning layer on retinoid nights. Many people use both: 345 by day, Reju 5000 at night.
What does "5000" mean in Dr.Althea PDRN Reju 5000 Cream?
It's the PDRN concentration: 5,000 parts per million, or 0.5%. It isn't an ingredient count. On the US label PDRN is listed as "Sodium DNA."
Is Dr.Althea PDRN Reju 5000 Cream vegan, or is it salmon PDRN?
Ulta lists the cream as vegan, and Dr.Althea calls its ingredient "Biome PDRN." Some retailers describe it as probiotic-derived and one says salmon-derived. The INCI name sodium DNA doesn't say which. Check the brand packaging if this matters to you.
Is the Reju 5000 Cream at Ulta the same as Dr.Althea PDRN Reju 5000 Cream?
Yes. Ulta sells it as "Dr. Althea Reju 5000 Cream" in 0.7 oz (20 g), and its ingredient list matches the US formula shown below.
Can I use Dr.Althea PDRN Reju 5000 Cream with retinol, vitamin C or acids?
Yes. It contains no exfoliating acids or retinoids, so it layers easily. Apply your active serum first, then the cream. Beauty bloggers report using it on retinol nights to keep skin comfortable.
Is Dr.Althea PDRN Reju 5000 Cream good for oily or combination skin?
It's light enough for normal and combination skin, especially as a thin layer. If you're very oily, the 345 Relief Cream is usually the better match. If you follow a strict fungal-acne ingredient list, note that the cream contains olive-derived esters (cetearyl olivate, sorbitan olivate) that some trackers flag.
Does Dr.Althea PDRN Reju 5000 Cream contain silicones or fragrance?
It contains silicones (vinyl dimethicone, caprylyl methicone, dimethiconol) and has no added fragrance. It's also free of drying alcohol.
How long until I see results with Dr.Althea PDRN Reju 5000 Cream?
Skin feels hydrated and soft right away. Dr.Althea reports an improved skin-texture score after 2 weeks in its own trial. Give it a few weeks of steady AM and PM use to judge the smoother-looking finish. Individual results vary.
US ingredient deck verified against US retail listings, October 2026. Formulas can differ by country and change over time — the label on your bottle is the final word.
Product Details
Brand
Dr.Althea
Product
PDRN Reju 5000 Cream (sold at Ulta as "Reju 5000 Cream")
100% Authentic · US-Market ProductMIMOMART is a US distributor or buys directly from US distributors, so every product we sell is the US-market version with the ingredient list shown above. Our low price comes from a short supply chain — not gray-market, relabeled or overseas-reshipped stock. Your skin deserves the real thing, at the right price.
